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ea0029p1307 | Paediatric endocrinology | ICEECE2012

Randomized multicenter trial on patients with childhood craniopharyngioma (KRANIOPHARYNGEOM 2007): update after 49 months of recruitment

Muller H. , Gebhardt U. , Kortmann R. , Warmuth-Metz M. , Faldum A. , Pietsch T. , Sorensen N. , Calaminus G.

Despite high survival rates (92%) in patients with childhood craniopharyngioma (CP), quality of life (QoL) is frequently impaired due to sequelae such as severe obesity resulting from hypothalamic involvement of CP. Based on the results of the multicenter prospective study KRANIOPHARYNGEOM 2000 radical surgery is no appropriate treatment strategy in patients with hypothalamic involvement. Furthermore, tumour progression/relapses are frequent early events in CP patients. The an...

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ea0003p158 | Genetics | BES2002

Lack of association between polymorphic markers within 11b-hydroxysteroid dehydrogenase type 1 gene (HSD11B1) and obesity

Draper N , Echwald S , Sorensen T , Astrup A , Lavery G , Chalder S , Hewison M , Pedersen O , Stewart P

11beta-hydroxysteroid dehydrogenase regulates glucocorticoid action, by interconverting cortisone (E) to cortisol (F). The Type 1 isozyme (11betaHSD1) is an oxoreductase expressed in adipose tissue, where it may play a role in the pathogenesis of visceral obesity.We have characterised two polymorphic (CA)n microsatellite markers within intron 4 of the HSD11B1 gene, termed (CA)15 and (CA)19. In an earlier study evaluating a 'normal' population (MONICA co...

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Endocrine Abstracts

Randomized multicenter trial on patients with childhood craniopharyngioma (KRANIOPHARYNGEOM 2007): update after 49 months of recruitment

Lack of association between polymorphic markers within 11b-hydroxysteroid dehydrogenase type 1 gene (HSD11B1) and obesity

BiosciAbstracts